Words Ending With SIS
100 wordsWords ending in -SIS form one of English's most recognizable scientific and medical word families. This Greek suffix meaning 'process' or 'condition' gives us terminology for everything from cellular division to disease states, making these words essential for medical professionals and word game enthusiasts alike.
3-letter words
15-letter words
26-letter words
77-letter words
108-letter words
199-letter words
1510-letter words
1111-letter words
912-letter words
813-letter words
1014-letter words
415-letter words
316-letter words
1Pattern Guide
Insights and recommendations for these words.
The -SIS ending creates some of the most satisfying long words in competitive word games, combining high letter counts with unexpected playability.
Vocabulary & Language
Linguistic patterns and usage statistics
The suffix -SIS derives from Ancient Greek, where it indicated an action, process, or condition. In English, it predominantly forms nouns describing biological processes (mitosis, osmosis), medical conditions (psoriasis, neurosis), or states of being (crisis, basis). The suffix pairs reliably with Greek roots, which explains why -SIS words often sound technical—they were designed for scientific precision.
Total Words
639
0.2% of dictionary
Avg Length
10.5 letters
4.4 syllables
Top Scrabble
ZYGAPOPHYSIS
35 points
Longest Word
LYMPHOGRANULOMATOSIS
20 letters
Parts of Speech
This pattern is exclusively nouns—100% of words ending in -SIS function as nouns, with zero verbs, adjectives, or adverbs. The average word stretches to 10.5 letters with 4.4 syllables, reflecting the pattern's scientific vocabulary heritage where precision demanded longer, more specific terms.
Ancient Greek dominates this pattern overwhelmingly, reflecting the suffix's origins in scientific and philosophical Greek terminology. Many words traveled through New Latin and Late Latin before reaching English, as scholars coined medical and scientific terms by combining Greek elements with Latinate conventions. The etymology chain of HYPOTHESIS perfectly illustrates this journey: from Ancient Greek ὑπόθεσις through Latin and into Middle French before arriving in English.
Word Games
High-value words for board games
Short (2-4)
a female person who has the same parents as another person
Medium (5-7)
a process in which an agent causes an organic substance to break down into simpler substances; especially, the anaerobic breakdown of sugar into alcohol
growth from increase in cell size without cell division
Long (8+)
an infection of the lungs and skin characterized by excessive sputum and nodules
the anterior lobe of the pituitary body; primarily glandular in nature
Short (2-4)
a female person who has the same parents as another person
Medium (5-7)
a process in which an agent causes an organic substance to break down into simpler substances; especially, the anaerobic breakdown of sugar into alcohol
growth from increase in cell size without cell division
Long (8+)
an infection of the lungs and skin characterized by excessive sputum and nodules
Both Scrabble and WWF feature ZYMOSIS at 21 points as a top medium-length scorer. The real strategic difference emerges with longer words: LYMPHOGRANULOMATOSIS scores 33 points in Scrabble but jumps to 39 in WWF due to different letter valuations. For more accessible plays, AUXESIS offers solid points (14 in Scrabble, 15 in WWF) using common tiles. The Z-heavy options like ZYGOSIS provide reliable high scores across both games.
Wordle
5-letter words for daily puzzles
ARSIS makes a solid Wordle starter, testing the common consonants R and S while checking two vowel positions. Its five letters efficiently probe letter frequencies that appear across many -SIS words.
Length Extremes
Longest and shortest valid words
Longest
Shortest
The lone short word SIS (3 letters) stands as an informal outlier in a pattern dominated by medical and scientific terminology. The Greek combining tradition naturally produces lengthy compounds, with LYMPHOGRANULOMATOSIS stretching to 20 letters.
Hidden Gems
Rare but valid words to surprise opponents
someone skilled in the transcription of speech (especially dictation)
an infectious disease of domestic animals often resulting in spontaneous abortion; transmittable to human beings
an infection caused by fungi of the genus Monilia or Candida (especially Candida albicans)
periodic shedding of the cuticle in arthropods or the outer skin in reptiles
ECDYSIS describes the periodic shedding of outer skin in reptiles or the cuticle in arthropods—essentially, the scientific term for when snakes shed their skin. Beyond its biological precision, this seven-letter word uses common tiles and offers word game players an unexpected valid play when opponents might challenge it.
Popular crossword answers
Words frequently used in crossword puzzles with common clues.